Global trade restructuring is a net effect of the rapid geopolitical, technology, and environmental shifts happening and accelerating now. From the US-China trade war that is disrupting supply chains, to the advances of digital technology in all areas of life, to the demographic impact of resource loss and extreme weather, the current trade structure is under attack and will need to adapt. There are many angles to address these changes. Some can be applied to mitigate adverse effects, but most require a fundamental shift in paradigms and leveraging technology to effect socio-economic change. In the Philippines, the country faces challenges in sustaining its critical ICT industry and manufacturing sectors as well as supporting the transformation of the agriculture and financial services industries. The rise of artificial intelligence, blockchain, Internet of Things, 3D printing, and a host of related technologies alter industry dynamics in the BPO, automotive, retail, food production, banking and creative sectors. Underpinning all these is not just technology adoption to current business models, but a pivotal upgrading in human resources to drive productivity and innovative value-adding work. These require policy and regulatory changes in how work is defined, compensated, located, and protected. It also requires targeted investments in connectivity, training, and alternative workplaces.